Volume-based vs. voxel-based brain morphometry in Alzheimer's disease prediction
نویسندگان
چکیده
Alexis Roche, Daniel Schmitter, Bénédicte Maréchal, Delphine Ribes, Ahmed Abdulkadir, Meritxell Bach-Cuadra, Alessandro Daducci, Cristina Granziera, Stefan Klöppel, Philippe Maeder, Reto Meuli, and Gunnar Krueger Advanced Clinical Imaging Technology, Siemens Healthcare IM BM PI, Lausanne, Switzerland, Department of Radiology, University Hospital (CHUV), Lausanne, Switzerland, Biomedical Imaging Group, EPFL, Lausanne, Switzerland, Group of Pattern Recognition and Image Processing, University of Freiburg, Germany, Signal Processing Laboratory 5, EPFL, Lausanne, Switzerland, Service of Neurology, University Hospital (CHUV), Lausanne, Switzerland
منابع مشابه
An evaluation of volume-based morphometry for prediction of mild cognitive impairment and Alzheimer's disease
Voxel-based morphometry from conventional T1-weighted images has proved effective to quantify Alzheimer's disease (AD) related brain atrophy and to enable fairly accurate automated classification of AD patients, mild cognitive impaired patients (MCI) and elderly controls. Little is known, however, about the classification power of volume-based morphometry, where features of interest consist of ...
متن کاملP 24: Evaluation of the Voxel Based Morphometry in Quantitative Analysis of Brain MRI Images
Introduction: Voxel based morphometry is a type of statistical parametric mapping that can be used to investigate the effect of diseases such as epilepsy, Alzheimer's disease and Parkinson's disease or other agent such as skills on brain structure (white matter, gray matter and cerebrospinal fluid). The aim of this study is evaluate the effectiveness of this method in detection of differen...
متن کاملRegional flux analysis for discovering and quantifying anatomical changes: An application to the brain morphometry in Alzheimer's disease
In this study we introduce the regional flux analysis, a novel approach to deformation based morphometry based on the Helmholtz decomposition of deformations parameterized by stationary velocity fields. We use the scalar pressure map associated to the irrotational component of the deformation to discover the critical regions of volume change. These regions are used to consistently quantify the ...
متن کاملA comprehensive study of gray matter loss in patients with Alzheimer's disease using optimized voxel-based morphometry.
Voxel-based morphometry (VBM) has already been applied to MRI scans of patients with Alzheimer's disease (AD). The results of these studies demonstrated atrophy of the hippocampus, temporal pole, and insula, but did not describe any global brain changes or atrophy of deep cerebral structures. We propose an optimized VBM method, which accounts for these shortcomings. Additional processing steps ...
متن کاملInvestigating Structural Brain Changes of Dehydration Using Voxel-Based Morphometry
Dehydration can affect the volume of brain structures, which might imply a confound in volumetric and morphometric studies of normal or diseased brain. Six young, healthy volunteers were repeatedly investigated using three-dimensional T(1)-weighted magnetic resonance imaging during states of normal hydration, hyperhydration, and dehydration to assess volume changes in gray matter (GM), white ma...
متن کامل